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Now, patients have access to once-weekly injections and an oral formulation, semaglutide (Rybelsus®), for those who prefer to avoid needles.² GLP-1s and the ADA Guidelines: A New First-Line Therapy The American Diabetes Association’s 2024 Standards of Care are clear: GLP-1 RAs are often first-line agents for patients with type 2 diabetes who also have atherosclerotic cardiovascular disease, chronic kidney disease, or obesity.¹ For patients with a body mass index (BMI) of 30 kg/m² or higher or elevated cardiovascular risk, semaglutide or tirzepatide may be considered before initiating metformin, especially when weight loss or cardioprotection is the top priority.¹ More Than Just A1C Control While GLP-1s are effective for lowering blood glucose, the added clinical benefits are just as important: Weight loss : Many patients experience a reduction of 10 percent or more in total body weight.² ⁵ ⁶ Cardiovascular protection : Liraglutide, dulaglutide, and semaglutide have demonstrated reductions in major adverse cardiovascular events.¹ Renal protection : These agents may slow the progression of chronic kidney disease.¹ GLP-1s are also being studied for a wide range of potential uses, including nonalcoholic steatohepatitis (NASH), obstructive sleep apnea, heart failure with preserved ejection fraction, and even Alzheimer’s disease.¹ What APRNs Should Know Before Starting GI side effects, particularly nausea and vomiting, are the most common patient complaints

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PubMed Central, Hira, Tohru, et al