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These changes are typically indirect consequences of the weight loss process rather than a direct pharmacological effect of semaglutide itself

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Efficacy estimand: This analysis was not included in the statistical testing hierarchy, and as such, is hypothetical and was not controlled for multiplicity Study design OASIS 4 7,10 : A randomized, double-blind, placebo-controlled 64-week trial of 307 adults with obesity (BMI ≥30 kg/m²) or overweight (BMI 27 kg/m²-29.9 kg/m²) and ≥1 weight-related comorbid condition, such as treated or untreated dyslipidemia or hypertension