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Introduction Type 2 diabetes mellitus (T2DM) is one of the most prominent and socially significant problems ( The main function of incretins is to stimulate insulin secretion by the pancreatic β-cells of the islets of Langerhans ( In addition to metabolic functions, leptin is a pleiotropic inflammatory mediator and modulates glucose homeostasis and insulin release by reducing glucagon secretion ( Incretin-stimulated insulin secretion accounts for approximately 50% of the total insulin production ( The present study aimed to identify the mechanisms of interaction of critical regulators of carbohydrate metabolism using bioinformatics and experimental methods, and to assess their influence on the development of T2DM complicated by obesity

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Neither directly interacts with levothyroxine, but adding more oral medications to the mix increases the importance of strategic timing