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Other clinically developed small-molecule GcgR antagonists include PF-06291874, LY2409021, and LGD-6972 (RVT-1502), all of which have advanced to clinical trials but ultimately were not pursued further for the treatment of T2D or obesity due to the associated increases in circulating LDL-C, body weight, hepatic fat, and blood pressure [31]
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Additionally, the therapeutic benefits of thiazolidinediones, a class of drugs that activate the peroxisome proliferator-activated receptor gamma, are largely attributed to their ability to induce adiponectin
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