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The body's metabolic rate exists within a carefully regulated physiological range, and disrupting this balance without medical supervision may result in fatigue, muscle loss, and metabolic disorders
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For example, Nagashima and colleagues showed that administration of active GLP-1(7–36) amide via osmotic minipumps for 4 weeks decreased atherosclerotic lesions and macrophage numbers in the aortic wall in Apoe –/– mice on high-fat diet (HFD), compared with vehicle controls (1)
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