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5 GLP-1RAs influence addiction-related criteria in food consumption behaviors The Diagnostic and Statistical Manual of Mental Disorders (DSM-5) defines substance use disorders (SUDs) as conditions arising from maladaptive patterns of substance use across a range of drug classes, including alcohol, cannabis, opioids, stimulants, sedatives, hallucinogens, inhalants, and tobacco (DSM-V, 2013)