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This study also investigated the expression of DPP-4 and found it to be present on the vascular endothelium, including the local capillaries in the lamina propria adjacent to the GLP-1 producing L-cells, thus providing an explanation for the rapid degradation of the peptide once it had been released

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If your nausea is worst in the first 24 to 48 hours after injection and then improves, it is likely peak-related and may respond well to split dosing