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Some weight loss occurs through appetite suppression alone—typically 5–15% over several months

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Early clinical trials in diabetic patients have indicated that GLP-1RAs treatment is associated with improvements in health-related quality of life and well-being compared with insulin and sulfonylureas.174–176 A notably comparable study is the population-based cohort analysis by Gamble et al,174 which utilized UK databases to assess the incidence of new-onset depression or self-harm among new users of GLP-1RAs and dipeptidyl peptidase-4 inhibitors relative to sulfonylureas