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Never freeze semaglutide, as this can damage the molecular structure
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Semaglutide shares ~94% homology with GLP-1 through an Ala 8 →2-aminoisobutyric acid (Aib8) substitution, which protects against DPP-4 degradation and includes a C18 diacid fatty acyl chain at Lys 26 , which both enhances albumin binding and extends its half-life
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