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Real-world studies The observational CVD-REAL study, which retrospectively evaluated over 300 000 people with type 2 diabetes, found that SGLT2 inhibitors were associated with a 39% lower risk of HF and a 51% lower risk of all-cause mortality compared with alternative oral glucose-lowering drugs, whether individuals had established CVD or not (Kosiborod et al, 2017)
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Elevated values may indicate inflammation or fluid imbalance factors that affect metabolic signalling
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