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(Table 2) [26, 35]
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As an example, several sulfonylurea drugs, such as tolbutamide, directly serve to impinge the Epac2A/Rap1 signaling (Zhang et al., 2009), which is essential for the cAMP-induced insulin secretion in pancreatic β-cell ( Besides K ATP channels, other different types of ion channels, including K + channels such as two-pore domain K + (K 2P ) channels, calcium-activated K + (K Ca 2+ ) channels, voltage-gated K + (Kv) channels, and inwardly rectifying K + (Kir) channels, as well as voltage-gated Ca 2+ channels (VGCCs), Na + channels, transient receptor potential (TRP) channels and Cl − channels are present in β-cells in the pancreatic islets of Langerhans (Thompson and Satin, 2021), with substantial functional roles in governing the resting membrane potential and tuning the action potential of target cells (Thompson and Satin, 2021
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