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Pharmacotherapy for obesity: GLP-1 based therapies Three GLP-1 based therapies, liraglutide and semaglutide (both GLP-1 receptor agonists) and tirzepatide (a glucose-dependent insulinotropic polypeptide [GIP]/GLP-1 dual receptor agonist) are currently approved by the US Food and Drug Administration for the treatment of overweight and obesity as an adjunct to a reduced-calorie diet and increased physical activity [[21], [22], [23]]
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