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Las guías de la American Diabetes Association (ADA) reconocen a los agonistas del receptor de GLP-1 como opciones terapéuticas recomendadas para pacientes con diabetes tipo 2, especialmente como terapia inicial para aquellos con enfermedad cardiovascular aterosclerótica establecida, alto riesgo cardiovascular, enfermedad renal crónica o insuficiencia cardíaca, independientemente del uso de metformina
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