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In adults with overweight or obesity (without diabetes) the semaglutide 2.4 mg dose produced an average weight reduction of about 15% of baseline body weight over ~68 weeks in the STEP 1 trial, a result that surprised many clinicians because it brought pharmacologic outcomes into a range previously associated with surgical interventions
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The individual underwent multiple tests including upper and lower endoscopies, a hepatobiliary iminodiacetic acid (HIDA) scan, abdominal Doppler blood flow study, as well as multiple medications to relieve the gastroparesis symptoms
