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Step 4: Oral NSAIDs (Days 21-28) Ibuprofen 400 to 600 mg every 6 to 8 hours with food, not to exceed 2,400 mg per day Alternatively, naproxen 220 to 440 mg every 8 to 12 hours with food Use the lowest effective dose for the shortest duration needed Discontinue once pain is controlled for 48 consecutive hours Oral NSAIDs address both inflammatory and mechanical components
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The primary outcome was the change in MDS-UPDRS Part 3 scores
