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In the literature, pro-inflammatory microglia are often termed “M1” as opposed to “M2” microglia, which comprise a subtype of activated microglia (commonly referred to as “alternatively activated” or “anti-inflammatory”) that secrete anti-inflammatory cytokines and exhibit other reparative functions

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We also detected a clear difference in GLP-1R internalisation triggered by orforglipron versus danuglipron, with the latter showing a similar level of receptor internalisation to that of exendin-4, while the former resulted in reduced receptor internalisation 5 minutes post-agonist exposure