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메트포르민 단독투여군을 대상으로 한 DURATION 2 연구에 따르면, 엑세나타이드 LAR를 추가로 투여한 경우 시타글립틴 또는 피오글리타존을 추가해 투여한 경우에 비해 A1C 수치의 감소폭이 큰 것으로 나타났다(Lancet 2010;376:431-9)

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