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Digestive enzymes are not a standard, evidence-backed treatment for these side effects, so current guidance focuses on dose titration, smaller low-fat meals, hydration, and sometimes anti-nausea meds.43 However, some clinicians and patients are experimenting with broad-spectrum enzyme blends to see if meals feel less “stuck,” but this use is based on clinical experience rather than trials, so it’s important to loop in your prescriber before trying enzymes alongside a GLP-1
