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The decision to use tirzepatide in MS patients should be based on: Presence of appropriate indications (type 2 diabetes or obesity with BMI ≥30 kg/m² or ≥27 kg/m² with weight-related comorbidity) Absence of contraindications Patient-specific factors including MS disease activity, functional status, and treatment goals Coordination between neurology and primary care/endocrinology teams Future research priorities should include prospective observational studies examining metabolic medication safety and efficacy in MS cohorts, as well as exploratory studies investigating whether weight loss and metabolic optimization influence MS disease trajectories
