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20,21 Signal transduction occurs after GLP-1R agonists bind to GLP-1Rs, mirroring a GLP-1 bioactivity effect favourable for patients with T2D, where this incretin therapy lowers blood glucose levels by stimulating insulin secretion from β-cells
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42 However, in a phase 3 trial, no case of medullary thyroid carcinoma or C cell hyperplasia was observed in patients after 3 years of treatment with liraglutide 3.0 mg
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