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The incretin pathway culminates in the release of glucagon-like peptide 1 (GLP1) which potentiates glucose-dependent insulin release and glucagon suppression
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To test if the specific amino acid changes at the DPP-4 cleavage site in pGLP-1 and eGLP-1 result in resistance to degradation, we compared their cleavage to that of human GLP-1 (hGLP-1) and the DPP-4 resistant exendin-4 (Ex-4) (Fig
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