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The efficacy endpoint for all of these trials was the incidence of laboratory-confirmed clinical influenza defined as meeting all the following criteria (all signs and symptoms must have been recorded within 24 hours): oral temperature greater than or equal to 99.0ºF (37.2ºC), at least one respiratory symptom (cough, sore throat, nasal congestion), at least one constitutional symptom (aches and pain, fatigue, headache, chills/sweats), and either a positive virus isolation or a four-fold increase in virus antibody titers from baseline

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To enhance the receptor’s expression, a BRIL fusion protein and an optimized maltose binding protein-maltose binding protein tag (OMBP-MBP) 54 were added to the N and C termini of the receptor to facilitate the receptor stability and expression (Supplementary Fig