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The STEP (Semaglutide Treatment Effect in People with obesity) programme showed average weight reductions of approximately 14.9% over 68 weeks in the STEP 1 trial
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[5] Severe respiratory depression has been reported in a 5-year-old child with ultra-rapid CYP2D6 genotype and obstructive sleep apnea, who received a single 20 mg dose (approximately 1 mg/kg) of tramadol for postoperative pain related to adenotonsillectomy
