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Studies using a stabilized radiolabeled (Ser8)GLP-1 revealed rapid uptake into the brain after intravenous (i.v.) administration without self-inhibition when challenged with increased doses of unlabeled (Ser8)GLP-1 or upon inhibition of brain GLP-1 influx upon pretreatment with exendin (9–39)
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This slowing frustrates many people but does not necessarily indicate medication failure
