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Most patients experience significant weight loss and can lose 5-10% of their body weight over the course of 6 months with weekly injections

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Several reports support the existence of K-ATP–channel and L-type calcium channel–containing (LTCC-containing) Ca 2+ microdomains, or hotspots, in the plasma membrane of neuroendocrine cells, with channels preassembled with docked insulin granules, resulting in rapid exocytosis synchronized with membrane depolarization, a process disturbed in T2D (78)