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While the liver was previously thought to be the main target of metformin’s glucose-lowering effects, recent evidence suggests that other parts of the body, such as the gastrointestinal tract, also play a role in its overall clinical advantages

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Allergen immunotherapy (desensitisation), where indicated and available — in line with BSACI guidance and NICE CKS criteria — can provide long-term symptom relief without the need for ongoing pharmacological management