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The second step comprises an irreversible oxidative decarboxylation reaction catalyzed by the branched-chain α-keto acid dehydrogenase complex (BCKDH), which represents the rate-limiting step of the entire metabolic pathway and directs metabolism toward complete oxidation (19)

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One study from May in the European Journal of Clinical Pharmacology found that patients on retatrutide were more likely to report dysesthesia, which is the medical term for strange sensations on your skin