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This triple-agonist approach, targeting GLP-1, GIP, and glucagon receptors, produced the most dramatic weight loss results seen in any Phase 2 obesity trial

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The in vitro BBB model used here substantiated this, and we did not find GLP-1R expression in endothelial cells using electron microscopy, whereas expression in tanycytes lining the third ventricular wall of the ventromedial ARH was found