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cAMP elevation induced by GLP-1 can lead to its downstream protein kinase A (PKA) activation and enhanced signaling via cAMP-activated guanine nucleotide exchange factor (Epac) (Holz, 2004
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These structural differences may affect how they interact with GLP-1 receptors in the gastrointestinal tract and central nervous system, which could contribute to differences in nausea experienced
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