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When used along with a low-calorie diet and increased physical activity, semaglutide is indicated for the following conditions: Type 2 diabetes (Ozempic and Rybelsus) Weight management in patients with obesity (BMI 30 or more) and overweight (BMI 27 or more) with at least one health condition related to increased body weight, such as hypertension, heart disease, hypercholesterolemia (high cholesterol levels in the blood), and dyslipidemia (Wegovy) To reduce the risk of cardiovascular diseases (Ozempic and Wegovy) To prevent worsening kidney failure or end-stage kidney disease in patients with chronic kidney disease (CKD) and type 2 diabetes (Ozempic) MASH (metabolic dysfunction-associated steatohepatitis) or ​​nonalcoholic steatohepatitis in patients with moderate-to-advanced fibrosis (Wegovy) The 3 different brands: Ozempic, Wegovy, and Rybelsus Semaglutide is available under three brand names: Ozempic, Wegovy, and Rybelsus

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doi: 10.1186/s12967-025-06927-z 30