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In the case of the oral glucose administration, you’re seeing the solid dots—glucagon levels go down because as glucose becomes more available in the periphery, the pancreas will make less glucagon for the liver to respond to make less glucose Remember, glucagon is secreted by the pancreas as well and it acts primarily on the liver to regulate glucose output, glycogen breakdown, and glucose production And you can see with the oral glucose administration, the attenuation of glucagon is less than with the intravenous administration Again, that delta is referred to here as the incretin effect So, why does this happen
and metabolic balance so energy feels steadier and fullness feels more natural throughout the day.
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