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We believe that the receptor uses the ER as a bridge to access other cellular organelles, opening exciting possibilities to find new ways to improve diabetes therapies." Professor Alejandra Tomas Catala Department of Metabolism, Digestion and Reproduction The paper, published in Nature Communications, uncovers how the GLP-1 receptor (GLP-1R) forms a specialised signalling hub inside pancreatic β-cells that supports healthy mitochondria and boosts insulin secretion

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We evaluate the emerging potential of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) as a multifunctional therapeutic strategy to target this metabolic hepatic nexus