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Regarding the GLP-1/GIP/glucagon tri-agonist molecule retatrutide, the TRIUMPH-Outcomes program (54) will assess kidney outcomes as a co-primary endpoint, while mechanistic insights are expected from the J1I-MC-GZBU study, in which the effects of retatrutide on mGFR and kidney physiology by multiparametric kidney MRI are investigated
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In the inactive GCGR structure, ECL1 forms a β-hairpin conformation and runs in parallel with the stalk to form a compact β-sheet module
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