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In separate studies involving the administration of exendin-4 (in the form of sustained-release exenatide as Bydureon ® ) to humans with PD (13) and as a twice daily immediate release form (BID Byetta ® ) in AD (99), cerebrospinal fluid (CSF) concentrations of exendin-4 were approximately 2.1% and 1.4% of concomitant plasma levels, respectively
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