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27 Evidence From Clinical Trials The clinical evidence supporting the use of GLP-1RAs in HF has primarily emerged from cardiovascular outcome trials (CVOTs) in patients with T2D and dedicated HF trials ( Table 1 )

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Preliminary clinical evidence supports this hypothesis—studies in obese individuals treated with tirzepatide have shown a downward trend in the apnea–hypopnea index (AHI), suggesting that tirzepatide may have a beneficial effect on sleep-disordered breathing (28)