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Biopsy-proven NASH : Patients with histologically confirmed NASH, particularly those with significant inflammation or early fibrosis (F1-F2), may be considered for off-label GLP-1 therapy, especially if they have failed lifestyle modification or have contraindications to other therapies like vitamin E or pioglitazone

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The search strategy [(1 OR 2 OR 3) AND 4 AND 5] was used for CVOTs with GLP-1RAs and [(6 OR 7 OR 8) AND 4 AND 5] was used for CVOTs with DPP-4i