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3 Metabolic outcomes of GLP-1RAs in PCOS: from evidence synthesis to Bayesian probability integration The interpretation of clinical evidence presented below follows the core tension between “metabolic risk × fertility window,” as illustrated in Figure 1A: achieving metabolic optimization within a finite reproductive window while strictly adhering to discontinuation and washout protocols to mitigate periconception exposure risks

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Alterations in diet or changes in antihyperglycemic treatment are warranted when blood glucose levels are persistently above 7.8 mmol/L