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In a randomized, controlled clinical study (Study F), in adult patients with type 2 diabetes not using oral antidiabetic medications (n=518), a basal-bolus regimen of LANTUS once daily at bedtime or NPH insulin administered once or twice daily was evaluated for 28 weeks

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In this regard, an attractive alternative therapy is based on the use of metformin in combination with a GLP-1R agonist or DPP-IV inhibitor