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It should be noted, however, that the apolar residues of GLP-1 (Val 33 ), GIP (Leu 27 ), and glucagon (Met 33 ) that are aligned with Lys 27 of exendin 9–39 form an additional hydrophobic interaction site with the ECD of GLP-1 (Y69 ECD /L123 ECD ), GIPR (Y68 ECD /H115 ECD ), and GCGR (Y65 ECD /A118 ECD ), respectively

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And I think that’s why all of us opted to it, we didn’t want the side effects