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They found a lower risk of HF exacerbations, all-cause emergency department visits/hospitalizations, new-onset atrial arrhythmias, new-onset acute kidney injury, and pulmonary hypertension in GLP-1RAs plus SGLT2i cohort compared with the SGLT2i-only cohort, demonstrating a possible additive effect of a combination therapy [68]
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DPP4i have no intrinsic glucose-lowering activity, so their efficacy as anti-diabetic agents is related directly to their ability to inhibit DPP4 activity and is mediated through the effects of the substrates they protect
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