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It should be pointed out that previous study has shown that FGF21 with L98R and P171A changes could prevent aggregation in vitro and degradation in vivo , respectively, without interfering its binding to β-klotho [17]
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Interestingly, the concomitant administration of GLP-1 receptor agonists with a sulphonylurea in the in situ perfused rat pancreas led to uncoupling of the insulinotropic effect of GLP-1 from its glucose dependence [136]
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