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[19] [20] A cyclomaltodextrinase (CDase) from gut bacteria Lactobacillus plantarum degraded acarbose via two different modes of action to produce maltose and acarviosin, as well as glucose and acarviosine-glucose, suggest that acarbose resistance is caused by the human microbiome

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Furthermore, action on brain food reward regions (such as the pre-frontal cortex) is likely, either directly or through communication via homeostatic centres